Sialic acids sweeten a tumor's life
WebJun 12, 2014 · Sialic Acids Sweeten a Tumor's Life Abstract. Over four decades ago, specific tumor characteristics were ascribed to the increased expression of sialic acid... WebApr 18, 2024 · Büll C Stoel MA Den Brok MH Adema GJ ‘Sialic Acids Sweeten a Tumor’s Life’ Cancer Res 74 12 2014 3,199 3,204 10.1158/0008-5472.CAN-14-0728 24830719 Search in Google Scholar [8] Teoh, ST, Ogrodzinski, MP, Ross, C, Hunter, KW, Lunt, SY. ‘Sialic Acid Metabolism: A Key Player in Breast Cancer Metastasis Revealed by Metabolomics’, Front.
Sialic acids sweeten a tumor's life
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WebDec 17, 2024 · Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has been linked to immune evasion and metastatic spread, eventually by interaction with sialoglycan-binding lectins, including Siglecs and selectins. The … WebMay 15, 2014 · Increasing the α 2, 6 sialylation of glycoproteins may contribute to metastatic spread and therapeutic resistance in colorectal cancer. Park JJ , Lee M. Gut Liver, 7 …
Web2. Functions of Sialic Acids in Tumor Biology Sialic acids on tumor cell surfaces are aberrantly expressed during tumor transformation and malignant progression. In general, hypersialylation is frequently observed in tumor tissues compared to corresponding normal tissue [25]. The total sialic acid in serum or glycolipid-bound sialic acids is WebSialic acid sugar-carrying glycans, sialoglycans, are aberrantly expressed on many tumor cells and have emerged as potent regulatory molecules involved in creating a tumor-supportive microenvironment. Sialoglycans can be recognized by sialic acid-binding immunoglobulin-like lectins (Siglecs), a family of immunomodulatory receptors. Most …
WebReview Sialic Acids Sweeten a Tumor's Life Christian B€ull, Marieke A. Stoel, Martijn H. den Brok, and Gosse J. Adema Abstract Over four decades ago, specific tumor … WebJun 15, 2014 · Figure 1. Aberrant sialylation favors tumor growth and progression. Several factors (e.g., oncogenes, hormones, or chemotherapy) increase the expression of …
WebJun 18, 2012 · Mechanisms and Different Pathways of Anticancer Drugs on Tumor Sialic Acids. Many research studies have shown patients with tumors that have high levels of sialyl Lewis X antigens, which appear to be linked with a poor prognosis for patients, which is one of the most conspicuous pathologic features of sias in tumors clinically [17, 18]. ...
WebSialic acids represent a family of sugar molecules derived from neuraminic acid that frequently terminate glycan chains and contribute to many biological processes. Already … pool table challengesWeb2. Functions of Sialic Acids in Tumor Biology Sialic acids on tumor cell surfaces are aberrantly expressed during tumor transformation and malignant progression. In general, … pool table clip art freeWebThe total sialic acid in serum or glycolipid-bound sialic acids is significantly elevated in multiple cancers such as ovarian cancer, leukemia, colorectal cancer, and breast cancer … pool table clip art imagesWebJan 17, 2024 · 1. Introduction. Biomolecules including monosaccharides of carbohydrates, amino acids of proteins, fatty acid of lipids, and nucleic acids including DNA and RNA play … shared mailbox send copyWebthe serum sialic acid levels in mice bearing tumors. Since these four antineoplastic drugs are all DNA chelating agents, it was proposed that the inhibition of tumor sialic acids by these drugs might be through DNA the template via two ways. Since we have found no effect of antineoplastic drugs on serum sialic acid levels in normal mice ... shared mailbox sending duplicate emailsWebSialic acids are important molecule with high structural diversity. They are known to occur in higher animals such as Echinoderms, Hemichordata, Cephalochorda, and Vertebrata and … pool table clearance to wallWebSialic acids (SA), negatively charged nine-carbon sugars, have long been implicated in cancer metastasis since 1960's but its detailed functional roles remain elusive. We … pool table cloth cheap