Phgdh and bone

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August undefined, 2024

WebTanshinone has been shown to affect osteoclast differentiation; however, the role of tanshinone in osteoporosis suggests that tanshinone effectively inhibits ovx-induced … WebApr 13, 2024 · As expected, overexpression of PHGDH increased the level of serine in the CM (Supplementary Fig. 5g), while the CM collected from PHGDH-overexpressing APR1 cells inhibited megakaryocytic ...

Phosphoglycerate dehydrogenase - Wikipedia

WebJan 4, 2024 · Phosphoglycerate dehydrogenase (PHGDH) is the first and rate-limiting enzyme in the de novo serine synthesis pathway, and it has been attributed to bortezomib … WebNov 14, 2016 · Phosphoglycerate dehydrogenase (PHGDH) is the metabolic enzyme responsible for shunting the glycolytic intermediate 3-phosphoglycerate to the serine synthesis pathway. In breast cancer and several other types of cancer, increased PHGDH expression is associated with patient mortality. eric ashbaugh

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WebJan 26, 2024 · Here, the rate-limiting enzyme in the biosynthesis of serine from glucose, 3-phosphoglycerate dehydrogenase (PHGDH), is examined, and an inverse correlation … WebJun 8, 2016 · PHGDH-deficient cells exhibited increased oxidant levels and apoptosis, as well as loss of BCSC enrichment, in response to treatment with carboplatin or doxorubicin. PHGDH-deficient cells were relatively weakly tumorigenic and tumors that did form were deficient in BCSCs, abolishing metastatic capacity. WebMar 21, 2024 · PHGDH (Phosphoglycerate Dehydrogenase) is a Protein Coding gene. Diseases associated with PHGDH include Phosphoglycerate Dehydrogenase Deficiency … find my iphone work if phone reset

The PHGDH enigma: Do cancer cells only need serine or also a …

The Influence of Mitochondrial Energy and 1C Metabolism on the …

WebJun 17, 2024 · Mitochondria are the main energy factory in living cells. To rapidly proliferate and metastasize, neoplastic cells increase their energy requirements. Thus, mitochondria become one of the most important organelles for them. Indeed, much research shows the interplay between cancer chemoresistance and altered mitochondrial function. In this … WebJan 15, 2024 · PHGDH was identified as being overexpressed in osteosarcoma and correlated with significantly poorer relapse-free survival and overall survival in … find my iphone xboxWebDec 22, 2016 · These results complement an earlier study, which reported that an MDA-MB-231 subclone with increased bone metastasis overexpressed PHGDH, PSAT1, and PSPH (Pollari et al, 2011 ), although the authors of that study speculated on the potential role of serine in osteoclast, rather than BCSC, biology. find my iphonex

"WebApr 16, 2024 · In the canonical pathway of glucose-derived serine synthesis, Homo sapiens phosphoglycerate dehydrogenase (PHGDH) catalyzes the first, rate-limiting step. Genetic loss of PHGDH is toxic toward PHGDH-overexpressing breast cancer cell lines even in the presence of exogenous serine. " - Phgdh and bone

Phgdh and bone

WebPHGDH. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. … WebJan 26, 2024 · PHGDH inhibition combined with non-rapalog mTORC1 inhibition is synergistic Summary Osteosarcoma is the most common pediatric and adult primary malignant bone cancer. Curative regimens target the folate pathway, downstream of serine metabolism, with high-dose methotrexate.

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WebDec 9, 2014 · Forgotten since classic animal studies in the 1980s, the role of PHGDH as a potential therapeutic target and putative metabolic oncogene has recently reemerged following publication of two prominent papers near-simultaneously in 2011. WebMay 3, 2024 · Elevated levels of an enzyme called PHGDH in the blood of older adults could be an early warning sign of Alzheimer's disease. Researchers have consistently found high levels of PHGDH expression...

WebMay 5, 2024 · About a year later, Jia and coworkers [ 65] suggested high PHGDH protein expression could be used as an independent prognostic factor of colorectal cancer. 5.7. … WebWang et al. find that an E3 ubiquitin ligase, RNF5, promotes the ubiquitination and degradation of PHGDH protein. Acetylation is identified as a regulating signal in RNF5-mediated PHGDH degradation and is responsible for PHGDH protein accumulation. These findings provide a potential explanation for PHGDH overexpression in human cancers.

WebMay 1, 2014 · The PHGDH gene provides instructions for making the parts (subunits) that make up the phosphoglycerate dehydrogenase enzyme. Four PHGDH subunits combine … WebMultiple studies have now reported cases of NLS with homozygous mutations in the genes responsible for the enzymes of the serine biosynthesis pathway; PHGDH (phosphoglycerate dehydrogenase), PSAT1 (phosphoserine aminotransferase), and PSPH (phosphoserine phosphatase). 15–17 Although several NLS cases have been found to have a …

WebFeb 10, 2024 · In this study, we found that phosphoglycerate dehydrogenase (PHGDH), the first rate-limiting enzyme in the SSP, was significantly elevated in CD138 + cells derived from patients with relapsed MM. Moreover, high PHGDH conferred inferior survival in MM. ... Bone marrow (BM) specimens derived from healthy donors (n = 11), ...

WebProliferation of PHGDH-amplified cancer cell lines, and other lines that overexpress PHGDH without amplification, is inhibited by PHGDH knockdown. ... S Pollari, et al., Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis. Breast Cancer Res Treat 125, 421–430 (2011). Crossref. eric ashbahianWebMar 19, 2024 · INTRODUCTION. Thyroid nodules are very common, and their clinical importance lies in the fact that approximately 5% of thyroid nodules are malignant [].Using high-resolution ultrasonography (US), thyroid nodules were detected in 19% to 68% of randomly selected adults, with a higher prevalence in women and aged persons [].Due to … eric ashbridgeWebPhosphoglycerate dehydrogenase (PHGDH) is an enzyme that catalyzes the chemical reactions 3-phospho-D-glycerate + NAD + 3-phosphonooxypyruvate + NADH + H + 2-hydroxyglutarate + NAD + 2 … erica shaw sheets obituary