Nettet20. okt. 1997 · We investigated the role of leukocyte integrin transmembrane and cytoplasmic domains in initiating adhesion under flow and in microvillous localization. … NettetLeukocyte recruitment is a process comprising several steps orchestrated by adhesion molecules, chemokines, cytokines and endogenous regulatory molecules. Distinct …
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Nettet15. mar. 2011 · Leukocyte integrins of the β2 family are essential for immune cell-cell adhesion. In activated cells, β2 integrins are phosphorylated on the cytoplasmic Thr758, leading to 14-3-3 protein recruitment to the β2 integrin. The mutation of this phosphorylation site impairs cell adhesion, actin reorganization, and cell spreading. NettetVascular expressed adhesion molecules mediate leukocyte reactivity and activation by receptor-ligand binding. A number of different ligand molecules have been identified to mediate the interaction between endothelial cells and leukocyte subpopulations. In this study, the tissue expression of ELAM-1, CD62 (PADGEM, GMP-140), VACM-1 (INCAM … mmd 髪の毛 ボーン 入れ方
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Nettet1. sep. 2006 · Schematic structure of the leukocyte integrin. (A) The integrin's primary structure, including divalent cation-binding sites (Mg 2+ as red stars, and Ca 2+ as gray stars). (B,C) Schematic representations of the bent (inactive) and straightened (active) conformations of the integrin, respectively. NettetIn addition, certain integrins such as VLA-4, can also mediate leukocyte rolling under conditions of flow (3-5). The slowing down of leukocytes during rolling facilitates the … mmd 馬娘 モデル