Web4 de dez. de 2024 · In the last few years, one trial revealed that high-dose atorvastatin before primary PCI in patients presenting with STEMI was able to improve coronary flow downstream of the treated culprit vessel.18 Other small pilot studies have demonstrated intensive statin therapy in acute phase after STEMI reduce oxidized LDL (ox-LDL), … Web14 de mai. de 2014 · The current guidelines now recommend high-dose statins (atorvastatin 40-80 or rosuvastatin 20-40 mg daily) for those with clinical evidence of atherosclerotic cardiovascular disease (ASCVD), LDL >190 mg/dL, or a 10-year ASCVD risk of greater than 7.5%. The recommendations make 12.8 million new patients, many in …
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Web12 de abr. de 2024 · Moderate-intensity statin with ezetimibe combination therapy was associated with lower rates of intolerance-related drug discontinuation or dose reduction among patients aged ≥75 years (2.3% vs. 7.2%; p = 0.010) and those aged <75 years (5.2% vs. 8.4%; p < 0.001) (p for interaction = 0.159). Median LDL-C levels were 58 mg/dL in … Web1 de out. de 2024 · The PREVENTABLE trial is aiming to enroll 20,000 community-dwelling primary prevention patients age ≥75 and randomize individuals to atorvastatin 40 mg daily, or placebo. The primary outcomes include dementia and physical disability over 4 years. can hemorrhoids block your stool
Statin Therapy in Older Adults for Primary Prevention of ...
Web19 de mai. de 2024 · Atorvastatin 80 mg/day or Rosuvastatin 40 mg/day are defined as high dose of statin because those average daily dosages reduce plasma LDL-C levels by 50% or greater [ 10 ]. Compared to moderate/low dose, statins in high dose can elicit better cardiovascular outcome among established CVD cases [ 11 – 16 ]. Web4 de dez. de 2024 · In the last few years, one trial revealed that high-dose atorvastatin before primary PCI in patients presenting with STEMI was able to improve coronary flow … Web13 de ago. de 2016 · Although high-dose atorvastatin (80-mg) was associated with higher AE/SAE rates compared with lower atorvastatin doses (10–40-mg), far fewer Asian patients in the short-term trials received atorvastatin at the 80-mg dose (175 of 2175 patients that received atorvastatin), and this may confound the interpretation of AE rates for this dose. can hemorrhoids cause an upset stomach