Dichloromethane mutagenicity

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August undefined, 2024

WebDichloromethane is a lipophilic solvent of low relative molecular mass, which can readily cross biological membranes. Pulmonary uptake is rapid, approaching steady state within …

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Hepatic toxicity. Hepatic effects are commonly observed forms of toxicity following inhalation (Burek et al. 1984; Nitschke et al. 1988) or oral (Serota et al. 1986a) dichloromethane exposure in rodents. Changes observed in animals following dichloromethane exposure include liver foci/areas of alteration, … See more In 2011, the Integrated Risk Information System (IRIS) of the U.S. Environmental Protection Agency (EPA) released an updated Toxicological Review of Dichloromethane (Methylene Chloride) (U.S. EPA 2011). In … See more The toxicological review was developed according to the general risk assessment guidelines (National Research Council 1983, 1994). The literature search strategy was based on the … See more In summary, the IRIS Toxicological Review of Dichloromethane (U.S. EPA 2011) developed noncancer reference dose values for oral … See more Dichloromethane metabolism occurs primarily in the liver but also in lung tissues, particularly in mice. The PBPK model structure for dichloromethane traces back to one … See more WebMay 17, 2024 · Since the mutagenicity of DCM was significantly increased in TA100-GST compared with mock control (TA100-pCTC), GSTT1 is thought to be involved in the … earth tech solutions nehru place

The role of glutathione in the bacterial mutagenicity of ... - Pub…

WebMutagenicity is an important toxicological endpoint that requires thorough evaluation during the industrial chemical registration process. Regulatory requirements for mutagenicity assessment in registration of industrial chemicals vary in geographic regions (and in some cases by intended application). ... Methanol (90%) and dichloromethane ... WebThe results suggest that if an interaction between DCM and GSH is required for the activation of DCM to a bacterial mutagen, it occurs at low levels of endogenous GSH and is not significantly affected by GSH supplementation. Dichloromethane (DCM) vapour by inhalation is carcinogenic to rodents and is an in vivo rodent cell clastogen and a … WebGerm cell mutagenicity Ames test S. typhimurium Result: negative Mutagenicity (micronucleus test) Hamster - male and female Result: negative Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity No … earth tech services corp

Antimutagenic activity of commercial chicken-essence against ...

Dichloromethane mutagenicity

WebBiodegradation of dichloromethane (DCM) to environmentally acceptable products was demonstrated under methanogenic conditions (35 degrees C). When DCM was supplied … WebSep 1, 1983 · The metabolic activation and mutagenicity of dichloromethane and chlorofluoromethane were investigated using rat liver fractions and Salmonella typhimurium strain TA100. Both dihalomethanes gave a mutagenic response without the addition of rat-liver fractions. This response has been shown to be due to bacterial metabolism of the …

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WebJan 9, 2006 · Mutagenicity: mutagenic in salmonella typhimurium Ames assay : Gene mutation in hamster ovary cells (3,000 ppm) : DNA damage in mouse liver cells (400 u mol/L) OTHER DATA: Limited evidence of a carcinogenic effect. Component Carcinogenicity Dichloromethane (75-09-2) ACGIH: A3 - Confirmed animal carcinogen with unknown … WebU.S EPA Web Server

WebPT.SMART-LAB INDONESIA MSDS – DICHLOROMETHANE Page 2 MATERIAL SAFETY DATA SHEET DICHLOROMETHANE Revision : 02 Date: November 3rd, 2024 MSDS Number : 068 P202 Do not handle until all safety precautions have been read and understood. P261 Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P302 + P352 IF … WebIn vivo mutagenicity was analyzed by gpt mutation/Spi-assays in the livers of rats. In addition, gene and protein expression of CYP2E1 and GSTT1, the major enzymes …

WebJan 1, 1978 · The possible mutagenicity of the organic solvent dichloromethane was investigated with the mutation test as described by Ames et al. The compound was … WebDichloromethane was originally selected for substance evaluation in order to clarify concerns about: - Carcinogenic - Suspected mutagenic - Suspected reprotoxic - …

WebGerm cell mutagenicity No data available Carcinogenicity Evidence of a carcinogenic effect. IARC: 2A - Group 2A: Probably carcinogenic to humans (Dichloromethane) NTP: RAHC - Reasonably anticipated to be a human carcinogen (Dichloromethane) OSHA: OSHA specifically regulated carcinogen (Dichloromethane) Reproductive toxicity No …

WebThe dichloromethane extracts of SRM 1649 and SRM 1650 contained direct-acting mutagens in Salmonella strains TA98 and TA100; SRM 1650 was significantly more potent than SRM 1649 in either strain. Addition of S9 caused a large decrease in mutagenicity of each extract, although SRM 1650 remained more potent. c t recyclingWebfor mutagenicity of a cosmetic substance to be annexed in the Regulation (EC) No 1223/2009 should include tests to provide information on the three genotoxic endpoints, … ctre cross the roadWebProduct name : Dichloromethane Product Number : 270997 Brand : Sigma-Aldrich Supplier : Sigma-Aldrich 3050 Spruce Street SAINT LOUIS MO 63103 USA Telephone : +1 800-325-5832 ... Germ cell mutagenicity Genotoxicity in vivo - rat - Oral DNA damage Carcinogenicity Carcinogenicity - rat - Inhalation Tumorigenic:Carcinogenic by RTECS … earth tech servicesWebMay 4, 2024 · Mulaudzi et al. evaluated the cytotoxicity activities of petroleum ether, dichloromethane, ethanol and water extracts of S. cordatum by evaluating the mutagenicity using the Salmonella /microsome assay using the plate-incorporation procedure with Salmonella typhimurium tester strains TA98, TA100 and TA102 with and … ct reconstruction open sourceWebfor mutagenicity of a cosmetic substance to be annexed in the Regulation (EC) No 1223/2009 should include tests to provide information on the three genotoxic endpoints, namely 1) mutagenicity at the gene level, 2) chromosome breakage and/or rearrangements (clastogenicity), and 3) numerical chromosome aberrations (aneuploidy). This ctredcrossWebEnzyme-mediated dichloromethane toxicity and mutagenicity of bacterial and mammalian dichloromethane-active glutathione S-transferases Daniel Gisi, Thomas Leisinger & … ct red bookWebNov 28, 2016 · 1,2-Dichloropropane (1,2-DCP) and dichloromethane (DCM) are possible causative agents associated with the development of cholangiocarcinoma in employees … ct record fish