Chromopyrrolic
WebMay 1, 2015 · We provide the first experimental evidence for intermediates being involved in catalysis by RebD in generating the chromopyrrolic acid (CPA) scaffold of … WebMolecules 2024, 25, 256 8 of 16 Gene expression elucidated that 3 is solely required by the tetrameric hemoprotein StaD or RebD for the production of the chromopyrrolic acid 4 in staurosporine or rebeccamycin biosynthesis [45,49], contrary to the previous reports that both 2 and 3 are the precursors for the coupling reaction to yield 4 [38,45].
Chromopyrrolic
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WebDichlorochromopyrrolate synthase ( EC 1.21.3.9, RebD, dichlorochromopyrrolic acid synthase) is an enzyme with systematic name 2-imino-3- (7-chloroindol-3-yl)propanoate ammonia-lyase (dichlorochromopyrrolate-forming). [1] [2] This enzyme catalyses the following chemical reaction 4 2-imino-3- (7-chloroindol-3-yl)propanoate + O 2 WebOverall formation of aglycones K252c and arcyriaflavin A from their biosynthetic precursor chromopyrrolic acid involves four- and eight-electron oxidations, respectively. This …
WebCatalytic Mechanism and Relevance to Cytochrome cPeroxidase. In theP450reactioncycle(SIFig.7A),theferricenzymefirstbinds the substrate and initiates a … WebJun 6, 2007 · Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton. Staurosporine isolated from Streptomyces sp. …
WebJul 3, 2014 · This oxidized system tolerates substrates bearing various electron-donating or electron-withdrawing groups. With this methodology, several key intermediates of natural … WebMay 20, 2009 · Chromopyrrolic acid (CPA) oxidation by cytochrome P450 StaP is a key process in the biosynthesis of antitumor drugs (Onaka, H.; Taniguchi, S.; Igarashi, Y.; …
Chromopyrrolic acid is a pyrroledicarboxylic acid that is pyrrole-2,5-dicarboxylic acid in which the hydrogens at positions 3 and 4 have been replaced by indol-3-yl groups. It has a role as a bacterial metabolite. It is a member of indoles and a pyrroledicarboxylic acid.
WebAug 19, 2007 · The biosynthesis of rebeccamycin, an antitumor compound, involves the remarkable eight-electron oxidation of chlorinated chromopyrrolic acid. Although one … shutterfly mail for meWebchromopyrrolic acid (CHEBI:41625) ChEBI > Main CHEBI:41625 - chromopyrrolic acid Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models Formula … shutterfly magnet coupon codesWebMar 15, 2009 · HPLC analysis of chromopyrrolic acid (CPA) produced by S. albus J1074 strains containing plasmid pUWL201 (A) and pLinkOD (B). CPA is indicated by filled arrow (retention time 26 min). Download : Download full-size image Figure 3. MS analysis of chromopyrrolic acid (CPA). ESI-MS [M+H] +: m / z = 386.1. the pa keys registryWebAbbreviations: P450 or CYP, cytochrome P450; CPA, chromopyrrolic acid. Data deposition: Atomic coordinates and structure factors have been deposited in the Protein Data Bank, www.pdb.org (PDB ID codes 2Z3T and 2Z3U). ¶To whom correspondence may be addressed. E-mail: [email protected] or onaka@ pu-toyama.ac.jp. shutterfly magnet coupon codeWebJan 3, 2024 · Indole pyruvic acid (IPA) is a versatile platform intermediate and building block for a number of high-value products in the pharmaceutical and food industries. … shutterfly mail for me serviceWebMay 1, 2009 · Chromopyrrolic acid (CPA) oxidation by cytochrome P450 StaP is a key process in the biosynthesis of antitumor drugs (Onaka, H.; Taniguchi, S.; Igarashi, Y.; Furumai, T. Biosci. Biotechnol. Biochem. 2003, 67, 127-138), which proceeds by an unusual C-C bond coupling. Additionally, because CPA is immobilized by a hydrogen-bonding … the pakhtunwali isWebJun 6, 2007 · A key step in staurosporine biosynthesis is the formation of the indolocarbazole core by intramolecular C-C bond formation and oxidative decarboxylation of chromopyrrolic acid (CPA) catalyzed by cytochrome P450 StaP (StaP, CYP245A1). In this study, we report x-ray crystal structures of CPA-bound and -free forms of StaP. the pak group new braunfels