Chilled platelet study

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August undefined, 2024

WebChilled Platelet Study. Status: Recruiting. Description: The purpose of this research study is to compare the transfusion of cold-stored (refrigerated) platelets to standard room … WebCHIlled Platelet Study (CHIPS) STATUS Recruiting; End date Mar 31, 2024; participants needed 1000; sponsor Philip Spinella; Save Print Send. Updated on 21 October 2024 ...

CHIlled Platelet Study "CHIPS": Acute Blood Loss Clinical Trial...

WebFeb 2, 2012 · The main task for blood transfusion services is to maintain an adequate supply of safe and effective platelet products. Unfortunately, because of the potential risk of bacterial contamination, platelets have a very short shelf life of 5 days stored at 20-24°C with continuous gentle agitation. 2 Consequently, platelet products are often in ... WebThe CHIlled Platelet Study trial will compare the efficacy and safety of standard room temperature-stored platelets with platelets that are cold-stored (1°C-6°C), that is, … candace owens inclusivity

The Effect of Cold on Platelets. II. Platelet Function After Short …

WebResearch Grants Chilled Platelet Study (ChiPS), U.S. Department of Defense Subspecialties cardiovascular and thoracic anesthesiology, perioperative echocardiography Contact UPMC Presbyterian 200 Lothrop Street, Suite C-200 Pittsburgh, PA 15213 [email protected] (412) 647-3260 WebDec 21, 2024 · The CHIlled Platelet Study trial has been funded and will be implemented in approximately 20 clinical centers. Early randomization to enable procurement of cold-stored platelets with different storage durations will be required, as well as a platelet tracking system to eliminate platelet wastage and maximize trial efficiency and economy. ... WebMar 31, 2024 · Overview. A phase 3 randomized partial blind storage duration ranging study in patients undergoing complex cardiac surgery that will compare the transfusion of cold stored platelets to standard room temperature stored platelets. The primary objective is to establish that cold stored platelets have a non-inferiority (or superiority) to room ... candace owens jerry falwell

Use of electron microscopy to study platelets and thrombi

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WebApr 8, 2024 · Acute respiratory distress syndrome, need for and duration of renal support, renal failure, septic shock. Measures of end organ injury [ Time Frame: within 48 hours of first study platelet transfusion ] If BUN, creatinine, lactate, troponin, alanine … WebJan 10, 2003 · Chilling platelets clusters their von Willebrand (vWf) receptors, eliciting recognition of mouse and human platelets by hepatic macrophage complement … fish n chips shoesWebCold-stored platelets are experiencing a resurgence as a treatment for hypovolemic shock—a shift in transfusion practice that could impact lab technologists cross-trained to … fish n chips short sleeve button down shirt

"WebFeb 17, 2024 · Recent data have shown that cold platelets stored for up to 21 days may improve clotting function compared with room-temperature platelets stored for up to 5 to … " - Chilled platelet study

Chilled platelet study

Design and logistical considerations for the randomized

WebCHIPS (CHIlled Platelet Study) is a phase III, multicenter, randomized, double-blinded, adaptive, non-inferiority, storage duration ranging trial in adult and pediatric patients undergoing cardiac surgery that will compare the transfusion of cold-stored platelets at multiple storage durations to standard room temperature-stored platelets. WebAn ongoing randomized clinical trial, the CHIlled Platelet Study (CHIPS), is currently testing the safety and efficacy of cold stored platelets stored up to 21 days. The extended shelf-life would allow for increased availability and decreased wastage of platelet units. While the advantage of increased safety from

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WebThe CHI lled P latelet S tudy (CHIPS) is a Phase III, multicenter trial sponsored by the Department of Defense which aims to compare the effectiveness and safety of chilled platelets versus standard room temperature platelets in 1000 bleeding cardiac surgical patients (NCT04834414). WebApr 8, 2024 · No Study Results Posted on ClinicalTrials.gov for this Study. Krachey E, Viele K, Spinella PC, Steiner ME, Zantek ND, Lewis RJ. The design of an adaptive clinical trial to evaluate the efficacy of platelets stored at low temperature in surgical patients. J Trauma Acute Care Surg. 2024 Jun;84 (6S Suppl 1):S41-S46. doi: 10.1097/TA.0000000000001876.

WebTHE CHIPS TRIAL (CHIlled Platelet Study) The US (United States) military is funding a large clinical trial to evaluate the ability of cold stored platelets to prevent bleeding in …

WebTHE CHIPS TRIAL (CHIlled Platelet Study) The US (United States) military is funding a large clinical trial to evaluate the ability of cold stored platelets to prevent bleeding in adult and pediatric patients undergoing cardiac surgery compared to … WebExpected order for washed or volume reduced platelets. Patient with known anti-platelet antibodies. Platelet transfusion refractoriness due to anti-HLA antibodies. Known or …

WebCHIlled Platelet Study "CHIPS" (CHIPS) Official Title: CHIlled Platelet Study : Secondary IDs: Study Status. Record Verification: April 2024 ... within 24 hours prior to receiving …

WebJul 7, 2024 · Carter BloodCare began distribution of Cold Stored Platelets on January 17, 2024. This new blood component has been a valuable … fish n chips songWebPlatelet count increased after platelet transfusion for all study arms (P < 0.05). Multiple electrode aggregation response to all agonists increased after platelet transfusion for all … fish n chips showWebDec 9, 2024 · Clinical trials have shown improved bleeding cessation with cold platelets. 11 Studies from our group have shown that you can transfer platelets into the cold after 3 or 4 days without an obvious impact on the … candace owens invading canadaWebJul 3, 2024 · Electron microscopy has been a valuable tool for the study of platelet biology and thrombosis for more than 70 years. Early studies using conventional transmission and scanning electron microscopy (EM) provided a foundation for our initial understanding of platelet structure and how it changes upon platelet activation. fish n chips snettisham norfolk opening timesWebDec 21, 2024 · The CHIlled Platelet Study trial will compare the efficacy and safety of standard room temperature–stored platelets with platelets that are cold-stored … fish n chips singaporeWebJan 10, 2003 · We propose that platelets are thermosensors, primed at peripheral sites where most injuries occurred throughout evolution. Clearance prevents pathologic thrombosis by primed platelets. Chilled platelets bind vWf and function normally in vitro and ex vivo after transfusion into CR3-deficient mice. candace owens invade australiaWebThe CHIlled Platelet Study trial will compare the efficacy and safety of standard room temperature-stored platelets with platelets that are cold-stored (1°C-6°C), that is, chilled, with a maximum of storage up to 21 days in adult and pediatric patients undergoing complex cardiac surgical procedures. candace owens kyrie